coffee enema and glutathione Effects of a single dose (a) multiple doses (b) of the coffee enema glutathione s transferase

its efficacy remains controversial and it has some potentially deleterious side effects

This can be corrected by intracavernosal injection of an alpha-adrenergic agent such as epinephrine or metaraminol

Accessed 4 Aug 2023

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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide